diff --git a/meta/recipes-devtools/python/python3_3.10.6.bb b/meta/recipes-devtools/python/python3_3.10.6.bb
index f19cd50273..1b28728732 100644
--- a/meta/recipes-devtools/python/python3_3.10.6.bb
+++ b/meta/recipes-devtools/python/python3_3.10.6.bb
@@ -171,6 +171,9 @@ do_install:append:class-native() {
         # Nothing should be looking into ${B} for python3-native
         sed -i -e 's:${B}:/build/path/unavailable/:g' \
                 ${D}/${libdir}/python${PYTHON_MAJMIN}/config-${PYTHON_MAJMIN}${PYTHON_ABI}*/Makefile
+        
+        # disable the lookup in user's site-packages globally
+        sed -i 's#ENABLE_USER_SITE = None#ENABLE_USER_SITE = False#' ${D}${libdir}/python${PYTHON_MAJMIN}/site.py
 }
 
 do_install:append() {